What organ's reduced function can put patients at risk for medication toxicity?

The correct answer is the kidneys. The kidneys play a crucial role in the excretion of medications and their metabolites from the body. When kidney function is reduced, the ability to filter and eliminate drugs efficiently is compromised. This can lead to an accumulation of medications in the bloodstream, increasing the risk of toxicity.

Conditions such as chronic kidney disease or acute kidney injury can significantly impact renal clearance, making it essential for healthcare providers to monitor medication dosages and adjust them accordingly for patients with reduced kidney function.

While liver function is also important for drug metabolism, it is not the correct answer in this context, as the kidneys primarily handle the excretion part. The lungs are involved in gas exchange rather than medication clearance, and the pancreas primarily regulates metabolism related to insulin and glucose rather than directly affecting medication toxicity.